In Senegal, Khaya senegalensis is subject to abusive and illegal exploitation, thus compromising its regeneration and the survival of its natural stand. It is in this context that this study aims to contribute to the reconstitution of Khaya senegalensis stands through the production of information allowing an optimal production of seedlings of this species in the nursery. The chosen device is a device in randomized complete blocks or Fischer blocks with 3 blocks or repetitions. Each block has 10 treatments with 20 sheaths each. The parameters studied are the height of the plants, the diameter at the collar, and the number of leaves of each plant. The analysis of the results obtained indicates that the greatest average plant heights were recorded with the compost (C) and the sand+compost (SC) treatments with 12.71 cm and 12.25 cm respectively. The lowest average heights (6.7 cm) were observed with sand (S) and sand mixed with potting soil (ST) with heights of 6.7 cm and 8.91 cm respectively. The largest diameter at the collar of Khaya senegalensis plants was obtained with the sand compost substrate (0.38 cm) and the smallest (0.25 cm) was observed with the sand substrate. The lowest leaf production is noted on the sand substrate alone (4.6 leaves/plant). However, it seems appropriate to continue this study by evaluating the effect of different types of pretreatments on the germination of Khaya senegalensis seeds in order to establish the basis for rapid production of Khaya senegalensis seedlings in the nursery.